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tempi syndrome refractory to current standards of therapy

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  • Lymphoma Action Find a trial

    Betalutin a phase 1 study to find the best dose of a new treatment called betalutin for people with diffuse large B-cell lymphoma that has come back or not responded to treatment 5 Jun 2020 Closed CXD101 a phase 1 trial looking at a new treatment called CXD101 for people with relapsed or refractory lymphoma and for other cancers 30 Jun 2020

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  • Monoclonal gammopathies of clinical significance

    Dec 04 2020 · TEMPI syndrome 23 . Mandatory major criteria Obligate criteria Major criteria 1. Generalized papular and sclerodermoid eruption Major criteria 1. Polyneuropathy (typically demyelinating) 1. Chronic urticarial rash 1. Cutaneous papules plaques and/or nodules most often yellow or orange in color 2. Evidence of monoclonal gammopathy 1.

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  • Classification of Childhood Aplastic Anemia and

    It is a major diagnostic challenge to distinguish among IBMFS myelodysplastic syndrome-type (MDS-type) refractory cytopenia of childhood (RCC) and severe aplastic anemia (SAA) due to

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  • Real world experience of approved chimeric antigen

    Nov 01 2020 · Introduction. It is estimated that approximately 77 240 new cases of non-Hodgkin lymphoma (NHL) will be diagnosed in the United States in 2020 .Diffuse large B-cell lymphoma (DLBCL) represents the most common subtype accounting for one-third of cases ont-line therapy for DLBCL consists of a chemoimmunotherapy regimen that combines cyclophosphamide doxorubicin

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  • TEMPI Syndrome Refractory to Current Standards of Therapy

    •The present case represents the first refractory to daratumumab •Telangiectasias represent a prominent manifestation of TEMPI syndrome and their presence when concurrent with other cardinal features of the disease should facilitate earlier diagnosis •This case highlights the need for additional treatments and further understanding of TEMPI syndrome

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  • UpToDate

    INTRODUCTION — Hemorrhagic cystitis (HC) is a sterile cystitis that is characterized by gross hematuria. It is most common in patients treated with ifosfamide and high-dose cyclophosphamide in the setting of bone and soft tissue sarcoma and hematopoietic cell transplantation or as a late toxicity of pelvic radiation therapy (RT) when the bladder is within the radiation treatment field.

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  • Common Terminology Criteria for Adverse Events (CTCAE)

    treatment or procedure that may or may not be considered related to the medical treatment or procedure. An AE is a term that is a unique representation of a specific event used for medical documentation and scientific analyses. Each CTCAE v4.0 term is a MedDRA LLT (Lowest Level Term).

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  • Guidelines for the Evaluation and Management of Status

    Apr 24 2012 · Status epilepticus (SE) treatment strategies vary substantially from one institution to another due to the lack of data to support one treatment over another. To provide guidance for the acute treatment of SE in critically ill patients the Neurocritical Care Society organized a writing committee to evaluate the literature and develop an evidence-based and expert consensus practice guideline.

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  • Monoclonal gammopathies of clinical significance

    Dec 04 2020 · TEMPI syndrome 23 . Mandatory major criteria Obligate criteria Major criteria 1. Generalized papular and sclerodermoid eruption Major criteria 1. Polyneuropathy (typically demyelinating) 1. Chronic urticarial rash 1. Cutaneous papules plaques and/or nodules most often yellow or orange in color 2. Evidence of monoclonal gammopathy 1.

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  • Long-Term Management of Vaccine-Induced Refractory

    The case report is suggested ischemic dermatopathy refractory to conventional therapy and suggests effective approaches to long-term management of the disease. KEY WORDS canine intravenous immunoglobulin ischemic dermatopathy vaccine. J. Vet. Med. Sci. 73(9) 1237–1240 2011 Ischemic dermatopathy is a syndrome that results from

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  • UpToDate

    There is no consensus regarding the preferred treatment of glucocorticoid-refractory hypereosinophilic syndrome (HES) that is not associated with a FIP1L1-PDGFRA mutation. Mepolizumab (Mep) is a monoclonal antibody directed against interleukin-5 (IL-5) a growth factor that is critical for eosinophil maturation and activation.

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  • ACC/AHA Guidelines for the Management of Patients With

    The cumulative event rates observed during the phase of medical management and at the time of PCI in the c7E3 Fab Antiplatelet Therapy in Unstable Refractory Angina (CAPTURE) (abciximab) Platelet Receptor Inhibition in Ischemic Syndrome Management in Patients Limited by Unstable Signs and Symptoms (PRISM-PLUS) (tirofiban) and Platelet

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  • Guidelines for the Evaluation and Management of Status

    Apr 24 2012 · The treatment of super-refractory status epilepticus a critical review of available therapies and a clinical treatment protocol. Brain. (Pt

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  • Guidelines for the Evaluation and Management of Status

    Apr 24 2012 · The treatment of super-refractory status epilepticus a critical review of available therapies and a clinical treatment protocol. Brain. (Pt

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  • Bortezomib to Treat the TEMPI Syndrome NEJM

    Bortezomib to Treat the TEMPI Syndrome Telangiectasias erythrocytosis monoclonal gammopathy perinephric-fluid collection and intrapulmonary shunting are characteristic of the TEMPI syndrome. A

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  • Bortezomib to Treat the TEMPI Syndrome NEJM

    Bortezomib to Treat the TEMPI Syndrome Telangiectasias erythrocytosis monoclonal gammopathy perinephric-fluid collection and intrapulmonary shunting are characteristic of the TEMPI syndrome. A

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  • UpToDate

    INTRODUCTION — Hemorrhagic cystitis (HC) is a sterile cystitis that is characterized by gross hematuria. It is most common in patients treated with ifosfamide and high-dose cyclophosphamide in the setting of bone and soft tissue sarcoma and hematopoietic cell transplantation or as a late toxicity of pelvic radiation therapy (RT) when the bladder is within the radiation treatment field.

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  • Optimal management of severe symptomatic gastroesophageal

    Jul 21 2020 · In a VA study from the USA patients on PPI therapy presenting with refractory heartburn to standard PPI therapy were prescribed twice daily omeprazole 20 mg for 2 weeks before meals and nearly one in five responded with a more than 50 symptom decrease 29 .

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  • Recent advances in the treatment of epilepsy dr.rajnish

    Jul 27 2015 · Briefly current treatment is Dravet Syndrome is a rare genetic epileptic encephalopathy So anti-inflammatory agents can be considered as candidates in the ongoing search for novel AEDs. FDA approved for treatment of refractory partial-onset seizures in patients 12 years and older based on 3 clinical trials in 1037 adults and

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  • Hyponatraemia and cirrhosis Gastroenterology Report

    Jan 21 2014 · Hyponatraemia is a common complication of advanced cirrhosis related to an impairment in the renal capacity for eliminating solute-free water causing a retention of water that is disproportionate to the retention of sodium thus leading to a reduction in serum sodium concentration and hypo-osmolality. The main pathogenic factor responsible for

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  • Recent advances in the treatment of epilepsy dr.rajnish

    Jul 27 2015 · Briefly current treatment is Dravet Syndrome is a rare genetic epileptic encephalopathy So anti-inflammatory agents can be considered as candidates in the ongoing search for novel AEDs. FDA approved for treatment of refractory partial-onset seizures in patients 12 years and older based on 3 clinical trials in 1037 adults and

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  • Guidelines for the Management of Pediatric Severe

    The treatment series included a total of 74 patients who received barbiturate therapy for refractory intracranial hypertension. Mortality was 43 . Two of the three studies assessed 43 patients for function at various timepoints and reported that 19 (44 ) had poor outcomes ( 166 174 ).

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  • TEMPI Syndrome Erythrocytosis in Plasma Cell Dyscrasia

    Jul 15 2018 · TEMPI (telangiectasias erythrocytosis with elevated erythropoietin monoclonal gammopathy perinephric fluid collections intrapulmonary shunting) syndrome is a newly described clinical entity that is generally considered a plasma cell dyscrasia with multiple system involvement. The etiology and pathophysiology of this condition remains elusive.

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  • Real world experience of approved chimeric antigen

    Nov 01 2020 · Introduction. It is estimated that approximately 77 240 new cases of non-Hodgkin lymphoma (NHL) will be diagnosed in the United States in 2020 .Diffuse large B-cell lymphoma (DLBCL) represents the most common subtype accounting for one-third of cases ont-line therapy for DLBCL consists of a chemoimmunotherapy regimen that combines cyclophosphamide doxorubicin

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  • TEMPI syndrome Genetic and Rare Diseases Information

    19 rows · Nov 06 2012 · TEMPI syndrome is a newly discovered multisystem condition named for 5

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  • Myelodysplastic Syndrome

    Chemo-refractory disease # of lines of chemotherapy needed to get into remission Age Prior chemo/radiation therapy History of preceding MDS Method of consolidation depends on risk High WBC at diagnosis Prior MDS or chemo/radiotherapy Chemo-refractory disease Older patients (controversial) Second remission Method of consolidation depends on risk

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  • Prolotherapy and SclerotherapyMedical Clinical Policy

    Number 0207. Policy. Aetna considers prolotherapy (also known as proliferant therapy proliferation therapy joint sclerotherapy or reconstructive ligament therapy) experimental and investigational for all indications including the following (not an all-inclusive list)

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